Photo of Professor Nigel Klein

Professor Nigel Klein

Director: Maternal, Child and Adolescent Health Programme

Professor of Infection and Immunity: University College London

Consultant : Great Ormond Street Hopsital, NHS Trust

Professor Nigel Klein

Institute of Child Health
30 Guilford Street

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T. +44 (0)207 9052891

Klein N, Palma P, Luzuriaga K, Pahwa S, Nastouli E, Gibb DM, Rojo P, Borkowsky

W, Bernardi S, Zangari P, Calvez V, Compagnucci A, Wahren B, Foster C, Munoz-Fernández MÁ, De Rossi A, Ananworanich J, Pillay D, Giaquinto C, Rossi P. Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission.

Lancet Infect Dis. 2015 Jul 14. pii: S1473-3099(15)00052-3.

Payne H, Mkhize N, Otwombe K, Lewis J, Panchia R, Callard R, Morris L, Babiker

A, Violari A, Cotton MF, Klein NJ, Gibb DM. Reactivity of routine HIV antibody tests in children who initiated antiretroviral therapy in early infancy as part of the Children with HIV Early Antiretroviral Therapy (CHER) trial: a retrospective analysis. Lancet Infect Dis. 2015 Jul;15(7):803-9.

Doyle, R. M., Alber, D. G., Jones, H. E., Fitzgerald, F., Klein, N., Peebles, D., & Harris, K. (2014). Term and preterm labour are associated with distinct microbial community structures in placental membranes which are independent of mode of delivery. Placenta. doi:10.1016/j.placenta.2014.10.007

Rosser, E. C., Oleinika, K., Tonon, S., Doyle, R., Bosma, A., Carter, N. A.,Klein N.  Mauri, C. (2014). Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production. Nat Med, 20 (11), 1334-1339.

Sandgaard, K. S., Lewis, J., Adams, S. ,Callard, R., Klein, N. (2014). Antiretroviral therapy increases thymic output in children with HIV. AIDS, 28 (2), 209-214.

Gibbons, D., Fleming, P., Virasami, A., Michel, M. L., Sebire, N. J., Costeloe, K., Carr, R., Klein, N., Hayday, A. (2014). Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants. Nat Med, 20 (10), 1206-1210.

Fisher, J. P., Yan, M., Heuijerjans, J., Carter, L., Abolhassani, A., Frosch, J., Klein N, Anderson, J. (2014). Neuroblastoma killing properties of Vδ2 and Vδ2-negative γδT cells following expansion by artificial antigen-presenting cells. Clin Cancer Res, 20 (22), 5720-5732.

Yin, D. E., Warshaw, M. G., Miller, W. C., Castro, H., Fiscus, S. A., Harper, L. M.. PENPACT-1 (PENTA 9/PACTG 390) Study Team. (2014). Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation. Pediatrics, 134 (4), e1104-e1116.

Bunupuradah, T., Duong, T., Compagnucci, A., McMaster, P., Bernardi, S., Kanjanavanit, S., Rampon, O., Faye, A., Saïdi, Y., Riault, Y., De Rossi, A., Klein, N., Ananworanich,J.,Gibb, D. (2013). Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions. AIDS, 27 (4), 579-589.

Fitzgerald, F., Doyle, R., Klein, N., Harris, K., & Alber, D. (2013). Short communication: Evidence that microbial translocation occurs in HIV-infected children in the united kingdom. AIDS Research and Human Retroviruses, 29 (12), 1589-1593.

Klein, N., Sefe, D., Jacobsen, M., et al. (2013). The Immunological and Virological Consequences of Planned Treatment Interruptions in Children with HIV Infection. PLoS ONE, 8 (10):e76582.

Picat MQ, Lewis J, Musiime V, Prendergast A, Nathoo K, Kekitiinwa A, Nahirya Ntege P, Gibb DM, Thiebaut R, Walker AS, Klein N, Callard R; ARROW Trial Team. Predicting patterns of long-term CD4 reconstitution in HIV-infected children starting antiretroviral therapy in sub-Saharan Africa: a cohort-based modelling study. PLoS Med. 2013 Oct;10(10):e1001542.

Paediatrics, HIV, Infectious Diseases and Immunology

Professor Nigel Klein is Professor and Consultant in Paediatric Infectious Diseases and Immunology at Great Ormond Street Children’s Hospital, London, and the Institute of Child Health (ICH), University College London (UCL). He trained at UCL, obtaining degrees in Anatomy and in Medicine. He established and led the Infectious Diseases and Microbiology Unit at ICH until 2014 and established and led the Department of Infection at UCL for 5 years until 2008. He has been working in the fields of Infectious Diseases for many years and has a particular interest in Meningitis, Sepsis, Innate Immunity, premature labour and HIV. He has been a member of the Wellcome Trust Infection and Immunity Board, Chair of the Grants Panel for Meningitis UK, and is currently a member of the Meningitis Research Foundation Grants Panel and Action Medical Research Panel. He has served on the Malawi Welcome Trust International Scientific Advisory Board and the MRC International Nutrition Group scientific Advisory Board. He is a member of the PENTA Immunology and Virology committee, on the editorial boards of two Journals and was a member of the Steering Group for the Technology Strategy Board’s Innovation Platform on the Detection and Identification of Infectious Agents (DIIA). He has published more than 280 papers, many in high impact journals. He has supervised more than 30 PhD students of which 16 have or are Clinical Fellows. He is currently on the Paediatric Medicines Expert Advisory Group of the Medicines and Healthcare Products Regulatory Agency.

He is taking up the position as Co-lead of the Maternal, Child, Adolescent Health Programme at the Africa Centre for Population Health. He will concentrate on establishing this new programme and will be exploring how events occurring in early life have a profound impact on future biological, psychological and social health of the rural population of KZN.