The summary below is meant to give a ‘taste’ of the ongoing work to address the overall objectives. Although seemingly rather exhaustive, note that many of these projects, although analyses are targeted to answer a specific question, draw from the data collected in the household and individual surveillance, as well as from the linked data with the HIV treatment and care programme. We are careful not to over-burden the community, and at all times communicate with the community before research grant applications are developed. The Centre’s research consists of Population, Clinical, and Social Science research, which is facilitated by the core Research Resources. The list provides detail, with main investigator noted.

Population-based Research

HIV Dynamics: understanding the HIV epidemic

1.       HIV incidence and prevalence; Causal pathways of HIV acquisition, transmission and treatment

2.       Molecular epidemiology: the where, who and why of HIV incidence; Surveillance resistant transmission  and the potential contribution to HIV dynamics

3.       Migration, Migration and HIV; Healthy migrant effect

4.       Socio-economic analyses

5.       Fertility trends and Impact of HIV on Fertility

6.       Partnerships and sexual behavior in the era of HIV and ART

7.       Adolescents, orphans ; Condom use in young adults

8.       Value of vaccination work

9.       Child mortality trends and HIV

10.   Modelling and Brass indirect techniques

Understanding the impact of HIV interventions

11.   Impact of ART on HIV epidemic dynamics

12.   Impact of ART on mortality in adults

13.   Impact of ART on early child mortality

Social Science

14.   Impilo Yamadoda

15.   Fatherhood and men’s health

16.   Ubumbano Lwentsha: Football and netball project

17.   HIV negative women of reproductive age in the MDP trial

18.   Preparing communities for a trial of early HIV treatment as prevention

Clinic Based

Pathogenesis

19.   Pathogenesis  of postnatal transmission of HIV

20.   Pregnancy related immunity issues

Immunity

21.   Innate immunity and mother-to-child transmission

22.   The impact of HIV co-infection on macrophage and T-cell recruitment to the site of spinal TB infection

Clinical Care
23.   HIV treatment and care –adults and children
24.   HIV in pregnancy – morbidity in mothers and their children
25.   TB and other non-HIV infectious diseases
26.   Mental Health: adherence, disclosure and resilience
27.   Understanding the epidemiology of Schistosomiasis

Health Systems
28.   Access to HIV treatment and care
29.   Human Resources in Health Care
30.   Quality of care

Interventions to prevent transmission or acquisition of HIV infection

31.    School-based youth intervention pilot

32.    MDP trial

33.   Kesho Bora Trial

34.   Treatment as Prevention

Evaluation and development of methods

35.   Induna project – mortality

36.   Tests for Recent Infection

37.   Primary Care Information System

38.   Validation of virological assays for molecular work

39.   Validation of DNA assays in breastmilk and DBS

40.   HIV genotyping validation

41.   Child health measurement

Research Resources

42.   Africa Centre Data Management Systems

43.   Africa Centre Virology Laboratory

44.   Bioinformatics Unit

45.   Hlabisa HIV treatment and care programme